Nine-men Bury fell to a late sucker punch from ex-Shaker Ethan Ebanks-Landell late into additional time as they were defeated 1-0 at Bramall Lane.
The Shakers were reduced to ten men just before the break after a late challenge from Jacob Mellis on the Blades striker Matt Done.
Greg Leigh suffered a second yellow card on the 84th minute, consequently Ebanks-Landell pounced on the opportunity to score the winner and extended the Shakers’ losing streak to nine league games.
In response to the 5-1 defeat at AFC Wimbledon on Saturday, three changes were made to the Shakers starting eleven at Bramall Lane.
Craig Jones and Tom Pope returned from injury to start the game, Scott Burgess was promoted from the substitute bench to start his first competitive game of the season, replacing Andrew Tutte, Niall Maher and Hallam Hope.
After a slow first ten minutes to the game, it was the home side that eventually went in search for the first goal of the game. Billy Sharp had an opportunity from six yards out, but his wild shot flew over the crossbar.
Jake Wright guided a long range shot on target which could not beat Williams, however, the Bury keeper was unable to hold the ball but snapped up the danger on the second attempt.
The hosts had an excellent chance to find the opening goal through Daniel Lafferty on the 27th minute. Bill Sharp’s delivery from the right wing found Lafferty in the penalty area, after he peeled off the defenders, although his header rose beyond the bar.
Eight minutes later, Chris Basham found himself on the end of a cross to the back post, but once again the header was too high for the target.
Jacob Mellis cut his game short with just two minutes to go until half time. His untimely challenge on Matt Done gave referee Ross Joyce the opportunity to show Mellis the red card, and leave the Shakers with ten men going into the break.
Former Shaker Leon Clarke came off the bench as a half time substitute for Sheffield United to face the side he left in the summer.
Greg Leigh started the half in a positive manner, running forward from his left back position and he fired a missile of a shot across goal, missing the target by inches.
On 56 minutes, another header at the back post from Basham was misguided over the bar following a corner from the right, leaving the home supporters frustrated by the host’s wasted chances.
With the Shakers down to ten players, Danny Mayor broke away on the counter attack with Vaughan in support, however, his through ball to Vaughan struggled to find a way through the home defence and the danger was subsequently cleared.
Minutes later, Clarke popped up in the Bury penalty area to divert the ball goal bound but Leigh was on hand to dramatically clear the ball off the goal line.
The ball finally hit the back of the net on 78 minutes through Clarke, the home supporters thought they had scored the winning goal but Clarke was deemed to have caused a foul inside the penalty area.
With six minutes of normal time remaining, Leigh left his side clinging on to an away point, as he mistimed his tackle and received a second yellow card.
Ben Williams was called into action by Caolan Lavery in additional time, then, Antony Kay topped off an excellent performance as he performed a fantastic clearance off the line to deny Harry Chapman.
The nine-men remaining on the pitch for the Shakers soldiered on until the end, but the hosts finally found the winning and only goal of the game on the 93rd minute. Ethan Ebanks-Landell poked in from close range to convert the all-important goal.
Next up for the Shakers is a home league game on Saturday against Millwall as the search for a clean sheet continues.
Attendance: 19,022 (234 Bury supporters)
Sheffield United starting line-up: Moore, Ebanks-Landall, O’Connell, Coutts, Basham, Lafferty, Wright (Chapman 63), Fleck, Scougall (Clarke 45), Sharp, Done (Lavery 74)
Unused subs: Hussey, Ramsdale, Brown, Whiteman
Bury starting line-up: Williams, Jones, Kay, Barnett (Danns 77), Leigh, Burgess (Tutte 60), Mellis, Soares, Mayor, Pope (Etuhu 45), Vaughan
Unused subs: Rachubka, Hope, Miller, Bedeau
Red Card: Mellis, Leigh